Monophosphoryl Lipid A(MLA) is basically used as a vaccine adjuvant. Adjuvants are added to vaccine to enhance immune response to produce more antibodies and long-term protection. Moreover, adjuvants can reduce the amount of antigen. MLA directly activates APC(Antigen Presenting Cell) expressing TLR-4, stimulating the production of cytokines and co-stimulatory molecules. MLA is well-known as novel adjuvant and is manufactured by only a few companies.
Its potential is expanded to a variety of indication such as allergy, cancer(with checkpoint inhibitor), Alzheimer’s disease and other immune response.
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